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    1. 출간예정도서

    Basic Virology 4e

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    도서명: Basic Virology 4e
    정   가: 190,000원
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    적립금: 3,600원 (2%)
    저   자: Martinez J. Hewlett
    출판사: Wiley-Blackwell
    ISBN  : 9781119314059
    출판일: 2021.07
    판   형: Softcover
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    판   수: 4e
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    의학서적전문 "성보의학서적"의 신간의학도서입니다.


    The foundational textbook on the study of virology

    Basic Virology, 4th Edition cements this series’ position as the leading introductory virology textbook in the world. It’s easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.

    This undergraduate-accessible book covers all the foundational topics in virology, including:

    • The basics of virology
    • Virological techniques
    • Molecular biology
    • Pathogenesis of human viral disease

    The 4th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.


    -도서목차-


    Preface

    Preface to the Second Edition

    Preface to the Third Edition

    Preface to the Fourth Edition

    Acknowledgements

    [PN]PART I

    [PT]VIROLOGY AND VIRAL DISEASE

    [PTOC]INTRODUCTION—THE IMPACT OF VIRUSES ON OUR VIEW OF LIFE

    AN OUTLINE OF VIRUS REPLICATION AND VIRAL PATHOGENESIS

    PATHOGENESIS OF VIRAL INFECTION

    VIRUS DISEASE IN POPULATIONS AND INDIVIDUAL ANIMALS

    VIRUSES IN POPULATIONS

    ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS

    THE DYNAMICS OF VIRUS- HUMAN INTERACTIONS

    PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS

    ADDITIONAL READING FOR PART I

    PROBLEMS FOR PART I

    [CN]CHAPTER 1

    [CT]INTRODUCTION—THE IMPACT OF VIRUSES ON OUR VIEW OF LIFE

    [CTOC] THE SCIENCE OF VIROLOGY

    The effect of virus infections on the host organism and populations—viral pathogenesis, virulence, and epidemiology

    The interaction between viruses and their hosts

    The history of virology

    Examples of the impact of viral disease on human history

    Examples of the evolutionary impact of the virus-host interaction

    The origin of viruses

    Viruses have a constructive as well as destructive impact on society

    Viruses are not the smallest self-replicating pathogens

    QUESTIONS FOR CHAPTER 1

    [CN]CHAPTER 2

    [CT]AN OUTLINE OF VIRUS REPLICATION AND VIRAL PATHOGENESIS

    [CTOC] VIRUS REPLICATION

    Stages of virus replication in the cell

    PATHOGENESIS OF VIRAL INFECTION

    Stages of virus-induced pathology

    Initial stages of infection—entry of the virus into the host

    The incubation period and spread of virus through the host

    Multiplication of virus to high levels—occurrence of disease symptoms

    The later stages of infection—the immune response

    The later stages of infection—virus spread to the next individual

    The later stages of infection—fate of the host

    QUESTIONS FOR CHAPTER 2

    [CN]CHAPTER 3

    [CT]VIRUS DISEASE IN POPULATIONS AND INDIVIDUAL ANIMALS

    [CTOC] THE NATURE OF VIRUS RESERVOIRSSome viruses with human reservoirs

    Some viruses with vertebrate reservoirs

    VIRUSES IN POPULATIONS

    Viral epidemiology in small and large populations

    Factors affecting the control of viral disease in populations

    ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS

    A mouse model for studying poxvirus infection and spread

    Rabies: where is the virus during its long incubation period?

    Herpes simplex virus latency

    Murine models

    Rabbit models

    Guinea pig models

    QUESTIONS FOR CHAPTER 3

    [CN]CHAPTER 4

    [CT]PATTERNS OF SOME VIRAL DISEASES OF HUMANS

    [CTOC] THE DYNAMICS OF HUMAN-VIRUS INTERACTIONS

    The stable association of viruses with their natural host places specific constraints on the nature of viral disease and mode of persistence

    Classification of human disease-causing viruses according to virus-host dynamics

    Viral diseases leading to persistence of the virus in the host are generally associated with viruses having long associations with human populations

    Viral diseases associated with acute, severe infection are suggestive of zoonoses

    PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS

    Acute infections followed by virus clearing

    Colds and respiratory infections

    Influenza

    Variola

    Infection of an “accidental” target tissue leading to permanent damage despite efficient clearing

    Persistent viral infections

    Papilloma and polyomavirus infections

    Herpesvirus infections and latency

    Other complications arising from persistent infections

    Viral and subviral diseases with long incubation periods

    Rabies

    HIV—AIDS

    Prion diseases

    SOME VIRAL INFECTIONS TARGETING SPECIFIC ORGAN SYSTEMS

    Viral infections of nerve tissue

    Examples of viral encephalitis with grave prognosis

    Rabies

    Herpes encephalitis

    Viral encephalitis with favorable prognosis for recovery

    Viral infections of the liver (viral hepatitis)

    Hepatitis A

    Hepatitis B

    Hepatitis C

    Hepatitis D

    Hepatitis E

    QUESTIONS FOR CHAPTER 4

    Part I Additional Reading

    [PN]PART II

    [PT]BASIC PROPERTIES OF VIRUSES AND VIRUS-CELL INTERACTION

    [PTOC]VIRUS STRUCTURE AND CLASSIFICATION

    CLASSIFICATION SCHEMES

    THE VIROSPHERE

    THE BEGINNING AND END OF THE VIRUS REPLICATION CYCLE

    LATE EVENTS IN VIRAL INFECTION: CAPSID ASSEMBLY AND VIRION RELEASE

    HOST IMMUNE RESPONSE TO VIRAL INFECTION

    NATURE OF THE VERTEBRATE IMMUNE RESPONSE

    LOCAL IMMUNITY

    PRESENTATION OF ANTIGENS TO IMMUNE REACTIVE CELLS

    CONTROL AND DYSFUNCTION OF IMMUNITY

    MEASUREMENT OF THE IMMUNE REACTION

    STRATEGIES TO PROTECT AGAINST AND COMBAT VIRAL INFECTION

    VACCINATION—INDUCTION OF IMMUNITY TO PREVENT VIRUS INFECTION

    EUKARYOTIC CELL–BASED DEFENSES AGAINST VIRAL REPLICATION

    ANTIVIRAL DRUGS

    BACTERIAL ANTIVIRAL SYSTEMS—RESTRICTION ENDONUCLEASES

    ADDITIONAL READING FOR PART II

    PROBLEMS FOR PART II

    [CN]CHAPTER 5

    [CT]VIRUS STRUCTURE AND CLASSIFICATION

    [CTOC] THE FEATURES OF A VIRUS

    Viral genomes

    Viral capsids

    Viral envelopes

    CLASSIFICATION SCHEMES

    The Baltimore scheme of virus classification

    Disease-based classification schemes for viruses

    THE VIROSPHERE

    QUESTIONS FOR CHAPTER 5

    [CN]CHAPTER 6

    [CT]THE BEGINNING AND END OF THE VIRUS REPLICATION CYCLE

    [CTOC] VIRAL ENTRY

    Animal virus entry into cells—the role of the cellular receptor

    Mechanisms of entry of nonenveloped viruses

    Entry of enveloped viruses

    Entry of virus into plant cells

    Entry of virus into plant cells

    Nonspecific methods of introducing viral genomes into cells

    LATE EVENTS IN VIRAL INFECTION: CAPSID ASSEMBLY AND VIRION RELEASE

    Assembly of helical capsids

    Assembly of icosahedral capsids

    Generation of the virion envelope and egress of the enveloped virion

    QUESTIONS FOR CHAPTER 6

    [CN]CHAPTER 7

    [CT] THE INNATE IMMUNE RESPONSE: EARLY DEFENSE AGAINST PATHOGENS

    HOST CELL–BASED DEFENSES AGAINST VIRUS REPLICATION

    Toll-like receptors

    Defensins

    Interferon

    Induction of interferon

    The antiviral state

    Measurement of interferon activity

    Other cellular defenses against viral infection

    Micro RNAs

    THE ADAPTIVE IMMUNE RESPONSE AND THE LYMPHATIC SYSTEM

    Two pathways of helper T response: the fork in the road

    The immunological structure of a protein

    Role of the antigen-presenting cell in initiation of the immune response

    Clonal selection of immune reactive lymphocytes

    Immune memory

    Complement-mediated cell lysis

    CONTROL AND DYSFUNCTION OF IMMUNITY

    Specific viral responses to host immunity

    Passive evasion of immunity—antigenic drift

    Passive evasion of immunity—internal sanctuaries for infectious virus

    Passive evasion of immunity—immune tolerance

    Active evasion of immunity—immunosuppression

    Active evasion of immunity—blockage of MHC antigen presentation

    Consequences of immune suppression to virus infections

    MEASUREMENT OF THE IMMUNE REACTION

    Measurement of cell-mediated (T-cell) immunity

    T-cell proliferation assay

    Tetramer Assay

    Measurement of antiviral antibody

    Enzyme-linked immunosorbent assays (ELISAs)

    Neutralization tests

    Inhibition of hemagglutination

    Complement fixation

    QUESTIONS FOR CHAPTER 7

    [CN]CHAPTER 8

    [CT]STRATEGIES TO PROTECT AGAINST AND COMBAT VIRAL INFECTION

    [CTOC]VACCINATION—INDUCTION OF IMMUNITY TO PREVENT VIRUS INFECTION

    Antiviral vaccines

    Smallpox and the history of vaccination

    How a vaccine is produced

    Live-virus vaccines

    Killed-virus vaccines

    Recombinant virus vaccines

    Capsid and Subunit vaccines

    DNA vaccines

    Problems with vaccine production and use

    EUKARYOTIC CELL–BASED DEFENSES AGAINST VIRUS REPLICATION

    Other cellular defenses against viral infection

    Small RNA-based defenses

    Enzymatic modification of viral genomes

    ANTIVIRAL DRUGS

    Targeting antiviral drugs to specific features of the virus replication cycle

    Other approaches

    BACTERIAL ANTIVIRAL SYSTEMS—RESTRICTION ENDONUCLEASES

    QUESTIONS FOR CHAPTER 8

    [PN]PART III

    [PT]WORKING WITH VIRUS

    [PTOC]VISUALIZATION AND ENUMERATION OF VIRUS PARTICLES

    REPLICATING AND MEASURING BIOLOGICAL ACTIVITY OF VIRUSES

    THE OUTCOME OF VIRUS INFECTION IN CELLS

    MEASUREMENT OF THE BIOLOGICAL ACTIVITY OF VIRUSES

    PHYSICAL AND CHEMICAL MANIPULATION OF THE STRUCTURAL

    COMPONENTS OF VIRUSES

    VIRAL STRUCTURAL PROTEINS

    CHARACTERIZING VIRAL GENOMES

    CHARACTERIZATION OF VIRAL PRODUCTS EXPRESSED IN THE

    INFECTED CELL

    CHARACTERIZATION OF VIRAL PROTEINS IN THE INFECTED CELL

    DETECTING AND CHARACTERIZING VIRAL NUCLEIC ACIDS

    IN INFECTED CELLS

    VIRUSES USE CELLULAR PROCESSES TO EXPRESS THEIR GENETIC

    INFORMATION

    THE MOLECULAR GENETICS OF VIRUSES

    GENETIC MANIPULATION OF VIRAL GENOMES

    DELIBERATE AND ACCIDENTAL ALTERATIONS IN VIRAL GENOMES

    AS A RESULT OF LABORATORY REPLICATION

    PROBLEMS FOR PART III

    ADDITIONAL READING FOR PART III

    [CN]CHAPTER 9

    [CT]VISUALIZATION AND ENUMERATION OF VIRUS PARTICLES

    [CTOC]Using the electron microscope to study and count viruses

    Counting (enumeration) of virions in the electron microscope

    Atomic Force Microscopy—a rapid and sensitive method for visualization of viruses and infected cells, potentially in real time.

    Indirect methods for “counting” virus particles

    QUESTIONS FOR CHAPTER 9

    [CN]CHAPTER 10

    [CT]REPLICATING AND MEASURING BIOLOGICAL ACTIVITY OF VIRUSES

    [CTOC]Cell culture techniques

    Maintenance of bacterial cells

    Plant cell cultures

    Culture of animal and human cells

    Maintenance of cells in culture

    Types of cells

    Loss of contact inhibition of growth and immortalization of primary cells

    THE OUTCOME OF VIRUS INFECTION IN CELLS

    Fate of the virus

    Fate of the cell following virus infection

    Cell-mediated maintenance of the intra- and intercellular environment

    Virus-mediated Cytopathology—changes in the physical appearance of cells

    Virus-mediated Cytopathology—changes in the biochemical properties of cells

    MEASUREMENT OF THE BIOLOGICAL ACTIVITY OF VIRUSES

    Quantitative measure of infectious centers

    Plaque assays

    Generation of transformed cell foci

    Use of virus titers to quantitatively control infection conditions

    Examples of plaque assays

    Statistical analysis of infection

    Dilution endpoint methods

    The relation between dilution endpoint and infectious units of virus

    QUESTIONS FOR CHAPTER 10

    [CN]CHAPTER 11

    [CT]PHYSICAL AND CHEMICAL MANIPULATION OF THE STRUCTURAL COMPONENTS OF VIRUSES

    [CTOC]VIRAL STRUCTURAL PROTEINS

    Isolation of structural proteins of the virus

    Size fractionation of viral structural proteins

    Determining the stoichiometry of capsid proteins

    The poliovirus capsid—a virion with equimolar capsid proteins

    Analysis of viral capsids that do not contain equimolar numbers of proteins

    CHARACTERIZING VIRAL GENOMES

    Sequence analysis of viral genomes

    Sanger sequencing

    High-throughput sequencing (HTS)

    Measuring the size of viral genomes

    Direct measure of DNA genome lengths in the electron microscope

    Rate zonal sedimentation and gel electrophoresis for measuring viral genome size

    The polymerase chain reaction—detection and characterization of extremely small quantities of viral genomes or transcripts

    QUESTIONS FOR CHAPTER 11

    [CN]CHAPTER 12

    [CT]CHARACTERIZATION OF VIRAL PRODUCTS EXPRESSED IN THE INFECTED CELL

    [CTOC]CHARACTERIZATION OF VIRAL PROTEINS IN THE INFECTED

    CELL

    Pulse labeling of viral proteins at different times following infection

    Use of immune reagents for study of viral proteins

    Working with antibodies

    The structure of antibody molecules

    Monoclonal antibodies

    Detection of viral proteins using immunofluorescence

    Related methods for detecting antibodies bound to antigens

    Use of bacterial staphylococcal A and streptococcal G proteins to detect

    and isolate antibody-antigen complexes

    Immunoaffinity chromatography

    DETECTING AND CHARACTERIZING VIRAL NUCLEIC ACIDS IN

    INFECTED CELLS

    Detecting the synthesis of viral genomes

    Characterization of viral mRNA expressed during infection

    In situ hybridization

    Further characterization of specific viral mRNA molecules

    USE OF MICROARRAY TECHNOLOGY FOR GETTING A COMPLETE

    PICTURE OF THE EVENTS OCCURRING IN THE INFECTED CELL

    QUESTIONS FOR CHAPTER 12

    [CN]CHAPTER 13

    [CT]VIRUSES USE CELLULAR PROCESSES TO EXPRESS THEIR GENETIC INFORMATION

    [CTOC] Prokaryotic DNA replication is an accurate enzymatic model for the process generally

    The replication of eukaryotic DNA

    The replication of viral DNA

    The effect of virus infection on host DNA replication

    Expression of mRNA

    Prokaryotic transcription

    Prokaryotic RNA polymerase

    The prokaryotic promoter and the initiation of transcription

    Control of prokaryotic initiation of transcription

    Termination of transcription

    Eukaryotic transcription

    The promoter and initiation of transcription

    Control of initiation of eukaryotic transcription

    Processing of precursor mRNA

    Posttranscriptional modification of precursor mRNA

    Visualization and location of splices in eukaryotic transcripts

    Post-transcriptional Regulation of eukaryotic mRNA function

    Virus-induced changes in transcription and posttranscriptional processing

    The mechanism of protein synthesis

    Eukaryotic translation

    Prokaryotic translation

    Virus-induced changes in translation

    QUESTIONS FOR CHAPTER 13

    [PN]PART IV

    [PT]REPLICATION PATTERNS OF SPECIFIC VIRUSES

    [PTOC]REPLICATION OF POSITIVE-SENSE RNA VIRUSES

    REPLICATION OF POSITIVE-SENSE RNA VIRUSES WHOSE GENOMES ARE TRANSLATED AS THE FIRST STEP IN GENE EXPRESSION

    POSITIVE-SENSE RNA VIRUSES ENCODING A SINGLE LARGE OPEN READING FRAME

    POSITIVE-SENSE RNA VIRUSES ENCODING MORE THAN ONE TRANSLATIONAL READING FRAME

    REPLICATION OF PLANT VIRUSES WITH RNA GENOMES

    REPLICATION OF BACTERIOPHAGE WITH RNA GENOMES

    REPLICATION STRATEGIES OF RNA VIRUSES REQUIRING RNA-DIRECTED mRNA TRANSCRIPTION AS THE FIRST STEP IN VIRAL GENE EXPRESSION REPLICATION STRATEGIES OF SINGLE-STRANDED RNA

    REPLICATION OF NEGATIVE-SENSE RNA VIRUSES WITH A MONOPARTITE GENOME

    INFLUENZA VIRUSES—NEGATIVE-SENSE RNA VIRUSES WITH A MULTIPARTITE GENOME

    OTHER NEGATIVE-SENSE RNA VIRUSES WITH MULTIPARTITE GENOMES

    VIRUSES WITH DOUBLE-STRANDED RNA GENOMES

    SUBVIRAL PATHOGENS

    REPLICATION STRATEGIES OF SMALL AND MEDIUM-SIZED DNA VIRUSES

    PAPOVAVIRUS REPLICATION

    THE REPLICATION OF ADENOVIRUSES

    REPLICATION OF SOME SINGLE-STRANDED DNA VIRUSES

    REPLICATION OF SOME NUCLEAR REPLICATING EUKARYOTIC DNA VIRUSES WITH LARGE GENOMES

    HERPESVIRUS REPLICATION AND LATENCY

    BACULOVIRUS, AN INSECT VIRUS WITH IMPORTANT PRACTICAL USES IN MOLECULAR BIOLOGY

    REPLICATION OF VIRUSES WITH DNA GENOMES THAT ENCODE THEIR OWN TRANSCRIPTION ENZYMES

    POXVIRUSES—DNA VIRUSES THAT REPLICATE IN THE CYTOPLASM OF EUKARYOTIC CELLS

    REPLICATION OF “LARGE” DNA-CONTAINING BACTERIOPHAGE

    A GROUP OF ALGAL VIRUSES SHARES FEATURES OF ITS GENOME STRUCTURE WITH POXVIRUSES AND BACTERIOPHAGES

    RETROVIRUSES: CONVERTING RNA TO DNA

    RETROVIRUS FAMILIES AND THEIR STRATEGIES OF REPLICATION

    MECHANISMS OF RETROVIRUS TRANSFORMATION

    DESTRUCTION OF THE IMMUNE SYSTEM BY HIV

    EUKARYOTIC CELLULAR GENETIC ELEMENTS RELATED TO RETROVIRUSES

    HIV AND OTHER LENTIVIRUSES

    HEPADNAVIRUSES: VARIATIONS ON THE RETROVIRUS THEME

    DISCUSSION AND STUDY QUESTIONS FOR PART IV

    ADDITIONAL READING FOR PART IV

    [CN]CHAPTER 14

    [CT]REPLICATION OF POSITIVE-SENSE RNA VIRUSES

    [CTOC] RNA VIRUSES—GENERAL CONSIDERATIONS

    A general picture of RNA-directed RNA replication

    REPLICATION OF POSITIVE-SENSE RNA VIRUSES WHOSE GENOMES ARE TRANSLATED AS THE FIRST STEP IN GENE EXPRESSION

    POSITIVE-SENSE RNA VIRUSES ENCODING A SINGLE LARGE OPEN READING FRAME

    Picornavirus replication

    The poliovirus genetic map and expression of poliovirus proteins

    The poliovirus replication cycle

    Picornavirus cytopathology and disease

    Flavivirus replication

    POSITIVE-SENSE RNA VIRUSES ENCODING MORE THAN ONE TRANSLATIONAL READING FRAME

    Two viral mRNAs are produced in different amounts during togavirus infection

    The viral genome

    The virus replication cycle

    Togavirus cytopathology and disease

    A somewhat more complex scenario of multiple translational reading frames and subgenomic mRNA expression: coronavirus replication

    Coronavirus replication

    Cytopathology and disease caused by coronaviruses

    REPLICATION OF PLANT VIRUSES WITH RNA GENOMES

    Viruses with one genome segment

    Viruses with two genome segments

    Viruses with three genome segments

    REPLICATION OF BACTERIOPHAGE WITH RNA GENOMES

    Regulated translation of bacteriophage mRNA

    [CS] Case Study

    QUESTIONS FOR CHAPTER 14

    [CN]CHAPTER15

    [CT]REPLICATION STRATEGIES OF RNA VIRUSES REQUIRING RNA-DIRECTED mRNA TRANSCRIPTION AS THE FIRST STEP IN VIRAL GENE EXPRESSION

    [CTOC] REPLICATION OF NEGATIVE-SENSE RNA VIRUSES WITH A MONOPARTITE GENOME

    The replication of vesicular stomatitis virus—a model for Mononegavirales

    The vesicular stomatitis virus virion and genome

    Generation, capping, and polyadenylation of mRNA

    The generation of new negative-sense virion RNA

    The mechanism of host shutoff by vesicular stomatitis virus

    The cytopathology and diseases caused by rhabdoviruses

    Paramyxoviruses

    The pathogenesis of paramyxoviruses

    Filoviruses and their pathogenesis

    Bornaviruses

    INFLUENZA VIRUSES—NEGATIVE-SENSE RNA VIRUSES WITH A MULTIPARTITE GENOME

    Involvement of the nucleus in flu virus replication

    Generation of new flu nucleocapsids and maturation of the virus

    Influenza A epidemics

    OTHER NEGATIVE-SENSE RNA VIRUSES WITH MULTIPARTITE GENOMES

    Orthobunyaviruses

    Virus structure and replication

    Pathogenesis

    Arenaviruses

    Virus gene expression

    Pathogenesis

    VIRUSES WITH DOUBLE-STRANDED RNA GENOMES

    Orthoreovirus structure

    The orthoreovirus replication cycle

    Pathogenesis

    SUBVIRAL PATHOGENS

    Hepatitis delta virus

    Viroids

    Prions

    [CS] Case Study

    QUESTIONS FOR CHAPTER15

    [CN]CHAPTER 16

    [CT]REPLICATION STRATEGIES OF SMALL AND MEDIUM-SIZED DNA VIRUSES

    [CTOC] DNA VIRUSES EXPRESS GENETIC INFORMATION AND REPLICATE THEIR GENOMES IN SIMILAR, YET DISTINCT, WAYS

    PAPOVAVIRUS REPLICATION

    Replication of SV40 virus—the model polyomavirus

    The SV40 genome and genetic map

    Productive infection by SV40

    Abortive infection of cells nonpermissive for SV40 replication

    The replication of papillomaviruses

    The HPV-16 genome

    Virus replication and cytopathology

    THE REPLICATION OF ADENOVIRUSES

    Physical properties of adenovirus

    Capsid structure

    The adenovirus genome

    The adenovirus replication cycle

    Early events

    Adenovirus DNA replication

    Late gene expression

    VA transcription and cytopathology

    Transformation of nonpermissive cells by adenovirus

    REPLICATION OF SOME SINGLE-STRANDED DNA VIRUSES

    Replication of parvoviruses

    Dependovirus DNA integrates in a specific site in the host cell genome

    Parvoviruses have potentially exploitable therapeutic applications

    DNA viruses infecting vascular plants

    Geminiviruses

    The single-stranded DNA bacteriophage —X174 packages its genes very compactly

    [CS] Case Study

    QUESTIONS FOR CHAPTER 16

    [CN]CHAPTER 17

    [CT]REPLICATION OF SOME NUCLEAR-REPLICATING EUKARYOTIC

    DNA VIRUSES WITH LARGE GENOMES

    [CTOC]HERPESVIRUS REPLICATION AND LATENCY

    The herpesviruses as a group

    Genetic complexity of herpesviruses

    Common features of herpesvirus replication in the host

    The replication of the prototypical alphaherpesvirus—HSV

    The HSV virion

    The viral genome

    HSV productive infection

    HSV latency and the LAT

    HSV transcription during latency and reactivation

    How do the LAT and other specific HSV genes function to accommodate reactivation?

    EBV latent infection of lymphocytes, a different set of problems and answers

    Pathology of herpesvirus infections

    BACULOVIRUS, AN INSECT VIRUS WITH IMPORTANT PRACTICAL USES IN MOLECULAR BIOLOGY

    Virion structure

    Viral gene expression and genome replication

    Pathogenesis

    Importance of baculoviruses in biotechnology

    [CS] Case Study

    QUESTIONS FOR CHAPTER 17

    [CN]CHAPTER 18

    [CT]REPLICATION OF CYTOPLASMIC DNA VIRUSES AND “LARGE” BACTERIOPHAGES

    [CTOC]POXVIRUSES—DNA VIRUSES THAT REPLICATE IN THE CYTOPLASM OF EUKARYOTIC CELLS

    The pox virion is complex and contains virus-coded transcription enzymes

    The poxvirus replication cycle

    Early gene expression

    Genome replication

    Intermediate and late stages of replication

    Pathogenesis and history of poxvirus infections

    Is smallpox virus a potential biological terror weapon?

    REPLICATION OF “LARGE” DNA-CONTAINING BACTERIOPHAGES

    Components of large DNA-containing phage virions

    Replication of phage T7

    The genome

    Phage-controlled transcription

    The practical value of T7

    T4 bacteriophage: the basic model for all DNA viruses

    The T4 genome

    Regulated gene expression during T4 replication

    Capsid maturation and release

    Replication of phage —— a “simple” model for latency and reactivation

    The phage — genome

    Phage — gene expression immediately after infection

    Biochemistry of the decision between lytic and lysogenic infection in E. coli

    Factors affecting the lytic/lysogenic “decision”

    A GROUP OF ALGAL VIRUSES SHARES FEATURES OF ITS GENOME STRUCTURE WITH POXVIRUSES AND BACTERIOPHAGES

    QUESTIONS FOR CHAPTER 18

    [CN]CHAPTER 19

    [CT]RETROVIRUSES: CONVERTING RNA TO DNA

    [CTOC]RETROVIRUS FAMILIES AND THEIR STRATEGIES OF REPLICATION

    The molecular biology of retrovirus replication

    Replication of retroviruses: an outline of the replication process

    Initiation of infection

    Capsid assembly and maturation

    Action of reverse transcriptase and RNase H in synthesis of cDNA

    Integration of the retroviral cDNA into the host genome

    Transcription and translation of viral mRNA

    Capsid assembly and morphogenesis

    MECHANISMS OF RETROVIRUS TRANSFORMATION

    Transformation through the action of a viral oncogene—a subverted cellular growth control gene

    Oncornavirus alteration of normal cellular transcriptional control of growth regulation

    Oncornavirus transformation by growth stimulation of neighboring cells

    CELLULAR GENETIC ELEMENTS RELATED TO RETROVIRUSES

    Retrotransposons

    The relationship between transposable elements and viruses

    QUESTIONS FOR CHAPTER 19

    [CN]Chapter 20

    [CT]HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND RELATED LENTIVIRUSES

    [CTOC] HIV-1 and related lentiviruses

    The origin of HIV-1 and AIDS

    HIV-1 and lentiviral replication

    Destruction of the immune system by HIV-1

    [CS] Case Study

    [CN]CHAPTER 21

    [CT]HEPADNAVIRUSES: VARIATIONS ON THE RETROVIRUS THEME

    [CTOC]The virion and the viral genome

    The viral replication cycle

    The pathogenesis of hepatitis B virus

    Prevention and treatment of hepatitis B virus infection

    Hepatitis D virus

    A plant “hepadnavirus”: cauliflower mosaic virus

    The evolutionary origin of hepadnaviruses

    [CS] Case Study

    QUESTIONS FOR CHAPTER 21

    [PN]PART V:

    [PT]MOLECULAR GENETICS OF VIRUSES

    [PT]MOLECULAR PATHOGENESIS

    [PT]VIRAL BIOINFORMATICS AND BEYOND

    [PT]VIRUSES AND THE FUTURE: PROBLEMS AND PROMISES

    DISCUSSION AND STUDY QUESTIONS FOR PART V

    ADDITIONAL READING FOR PART V

    [CN]CHAPTER 22

    [CT]THE MOLECULAR GENETICS OF VIRUSES

    [CTOC]Mutations in genes and resulting changes to proteins

    Analysis of Mutations

    Complementation

    Recombination

    Isolation of mutants

    Selection

    HSV thymidine kinase—a portable selectable marker

    Screening

    A TOOL KIT FOR MOLECULAR VIROLOGISTS

    Viral genomes

    Locating sites of restriction endonuclease cleavage on the viral genome—restriction mapping

    Cloning Vectors

    Cloning of fragments of viral genomes using bacterial plasmids\

    Cloning using phage l

    Cloning single stranded DNA with bacteriophage M13

    DNA animal virus vectors

    RNA virus expression systems

    Defective virus particles

    Mutagenesis of viral genes

    Site directed mutagenesis

    Generation of recombinant viruses

    Bacterial artificial chromosomes

    CRISPR-Cas

    QUESTIONS FOR CHAPTER 22

    [CN]CHAPTER 23

    [CT]MOLECULAR PATHOGENESIS

    [CTOC] AN INTRODUCTION TO THE STUDY OF VIRAL PATHOGENESIS

    ANIMAL MODELS

    Choosing a model: natural host vs. surrogate models

    Development of new models: transgenic animals

    Hybrid models: the SCID-hu mouse

    Considerations regarding the humane use of animals

    METHODS FOR THE STUDY OF PATHOGENESIS

    Assays of virulence

    Analysis of viral spread within the host

    Resolving the infection to the level of single cells.

    CHARCTERIZATION OF THE HOST RESPONSE

    Immunological Assays

    Use of transgenic mice to dissect critical components of the host immune response that modulate the viral infection

    QUESTIONS FOR CHAPTER 23

    [CN]Chapter 24

    [CT]Viral Bioinformatics

    [CTOC] Bioinformatics

    Biological Databases

    Biological Applications

    Systems Biology and Viruses

    Viral Internet Resources

    Questions for Chapter 24

    [CN]CHAPTER 25

    [CT]VIRUSES AND THE FUTURE—PROBLEMS AND PROMISES

    [CTOC]Clouds on the horizon—emerging disease

    What are the prospects of using medical technology to eliminate specific viral and other infectious diseases?

    Silver linings—viruses as therapeutic agents, viruses as technological tools, the place of viruses in the biosphere.

    Why study virology?

    QUESTIONS FOR CHAPTER 25

    Appendix

    Resource Center

    Technical Glossary

    Index


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