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  • Cardiovascular Physiology,11/e

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    도서명: Cardiovascular Physiology,11/e
    정   가: 65,000원
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    적립금: 1,750원 (3%)
    저   자: Achilles J. Pappano
    출판사: Elsevier
    ISBN  : 9780323594844
    출판일: 2018.11
    판   형: Softcover
    수량: 수량증가수량감소
    판   수: 11/e
    면   수: 300 page
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    Cardiovascular Physiology,11/e 수량증가 수량감소 (  1750)
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    상품상세정보

    의학서적전문 "성보의학서적"의 신간의학도서입니다.

    Gain a foundational understanding of cardiovascular physiology and how the cardiovascular system functions in health and disease. Cardiovascular Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book.

    • Helps you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, self-study questions, and a comprehensive exam to help prepare for USMLEs.
    • Keeps you current with the latest concepts in vascular, molecular, and cellular biology as they apply to cardiovascular function, thanks to molecular commentaries in each chapter.
    • Includes clear, 2-color diagrams that simplify complex concepts.
    • Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations.
    Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

    Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs.

    • Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology
    • Cloutier: Respiratory Physiology
    • Koeppen & Stanton: Renal Physiology
    • Johnson: Gastrointestinal Physiology
    • White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology
    • Hudnall: Hematology: A Pathophysiologic Approach

    -도서목차-

    Chapter 1 OVERVIEW OF THE CIRCULATION AND BLOOD

    The Circulatory System

    Blood

    Erythrocytes

    Leukocytes

    Lymphocytes

    Platelets

    Blood Is Divided into Groups by Antigens Located on Erythrocytes

    Summary

    Case 1-1

    Chapter 2 EXCITATION: THE CARDIAC ACTION POTENTIAL

    Cardiac Action Potentials Consist of Several Phases

    The Principal Types of Cardiac Action Potentials Are the Slow and Fast Types

    Ionic Basis of the Resting Potential

    The Fast Response Depends Mainly on Voltage-Dependent Sodium Channels

    Ionic Basis of the Slow Response

    Conduction in Cardiac Fibers Depends on Local Circuit Currents

    Conduction of the Fast Response

    Conduction of the Slow Response

    Cardiac Excitability Depends on the Activation and Inactivation of Specific Currents

    Fast Response

    Slow Response

    Effects of Cycle Length

    Summary

    Case 2-1

    Chapter 3 AUTOMATICITY: NATURAL EXCITATION OF THE HEART

    The Heart Generates Its Own Pacemaking Activity

    Sinoatrial Node

    Ionic Basis of Automaticity

    Overdrive Suppression

    Atrial Conduction

    Atrioventricular Conduction

    Ventricular Conduction

    An Impulse Can Travel Around a Reentry Loop

    Afterdepolarizations Lead to Triggered Activity

    Early Afterdepolarizations

    Delayed Afterdepolarizations

    Electrocardiography Displays the Spread of Cardiac Excitation

    Scalar Electrocardiography

    Dysrhythmias Occur Frequently and Constitute Important Clinical Problems

    Altered Sinoatrial Rhythms

    Atrioventricular Transmission Blocks

    Premature Depolarizations

    Ectopic Tachycardias

    Fibrillation

    Summary

    Case 3-1

    Chapter 4 THE CARDIAC PUMP

    The Microscopic and Gross Structures of the Heart

    Cardiac Muscle (myocardial) Cell Morphology

    Structure of the Heart: Atria, Ventricles, and Valves

    The Force of Cardiac Contraction Is Determined by Excitation-Contraction Coupling and the Initial Sarcomere Length of the Myocardial Cells

    Excitation-Contraction Coupling Is Mediated by Calcium

    Mechanics of Cardiac Muscle

    The Sequential Contraction and Relaxation of the Atria and Ventricles Constitute the Cardiac Cycle

    Ventricular Systole

    Echocardiography Reveals Movement of the Ventricular Walls and of the Valves

    The Two Major Heart Sounds Are Produced Mainly by Closure of the Cardiac Valves

    The Pressure-Volume Relationships in the Intact Heart

    Passive or Diastolic Pressure-Volume Relationship

    Active or End-Systolic Pressure-Volume Relationship

    Pressure and Volume during the Cardiac Cycle: The P-V Loop

    Preload and Afterload during the Cardiac Cycle

    Contractility

    The Fick Principle Is Used to Determine Cardiac Output

    Metabolism of ATP and its Relation to Mechanical Function

    Fatty Acid Metabolism

    Carbohydrate Metabolism

    Interrelation between Fatty Acid and Carbohydrate Metabolism

    Effects of plasma substrate and insulin levels

    Cardiac O2 Consumption and the Link between Ventricular Function and Cardiac Metabolism

    Summary

    Case 4-1

    Chapter 5 REGULATION OF THE HEARTBEAT

    Heart Rate is Controlled Mainly by the Autonomic Nerves

    Parasympathetic Pathways

    Sympathetic Pathways

    Higher Centers Also Influence Cardiac Performance

    Heart Rate Can Be Regulated via the Baroreceptor Reflex

    The Bainbridge Reflex and Atrial Receptors Regulate Heart Rate

    Respiration Induces a Common Cardiac Dysrhythmia

    Activation of the Chemoreceptor Reflex Affects Heart Rate

    Ventricular Receptor Reflexes Play a Minor Role in the Regulation of Heart Rate

    Myocardial Performance Is Regulated by Intrinsic Mechanisms

    The Frank-Starling Mechanism Is an Important Regulator of Myocardial Contraction Force

    Changes in Heart Rate Affect Contractile Force

    Myocardial Performance Is Regulated by Nervous and Humoral Factors

    Nervous Control

    Cardiac Performance Is Also Regulated by Hormonal Substances

    Summary

    Case 5-1

    Chapter 6 HEMODYNAMICS

    Velocity of the Bloodstream Depends on Blood Flow and Vascular Area

    Blood Flow Depends on the Pressure Gradient

    Relationship Between Pressure and Flow Depends on the Characteristics of the Conduits

    Resistance to Flow

    Resistances in Series and in Parallel

    Flow May Be Laminar or Turbulent

    Shear Stress on the Vessel Wall

    Rheologic Properties of Blood

    Summary

    Case 6-1

    Chapter 7 THE ARTERIAL SYSTEM

    The Hydraulic Filter Converts Pulsatile Flow to Steady Flow

    Arterial Elasticity Compensates for the Intermittent Flow Delivered by the Heart

    The Arterial Blood Pressure Is Determined by Physical and Physiological Factors

    Mean Arterial Pressure

    Cardiac Output

    Peripheral Resistance

    Pulse Pressure

    Stroke Volume

    Arterial Compliance

    Total Peripheral Resistance and Arterial Diastolic Pressure

    The Pressure Curves Change in Arteries at Different Distances from the Heart

    Blood Pressure Is Measured by a Sphygmomanometer in Human Patients

    Summary

    Case 7-1

    Chapter 8 The MICROCIRCULATION AND LYMPHATICS

    Functional Anatomy

    Arterioles Are the Stopcocks of the Circulation

    Capillaries Permit the Exchange of Water, Solutes, and Gases

    The Law of Laplace Explains How Capillaries Can Withstand High Intravascular Pressures

    The Endothelium Plays an Active Role in Regulating the Microcirculation

    The Endothelium is at the Center of Flow-Initiated Mechanotransduction

    The Endothelium Plays a Passive Role in Transcapillary Exchange

    Diffusion Is the Most Important Means of Water and Solute Transfer Across the Endothelium

    Diffusion of Lipid-Insoluble Molecules Is Restricted to the Pores

    Lipid-Soluble Molecules Pass Directly Through the Lipid Membranes of the Endothelium and the Pores

    Capillary Filtration Is Regulated by the Hydrostatic and Osmotic Forces Across the Endothelium

    Balance of Hydrostatic and Osmotic Forces

    The Capillary Filtration Coefficient Provides a Method to Estimate the Rate of Fluid Movement Across the Endothelium

    Hypoxia-inducible factor(s) and angiogenesis

    Pinocytosis Enables Large Molecules to Cross the Endothelium

    The Lymphatics Return the Fluid and Solutes That Escape Through the Endothelium to the Circulating Blood

    Summary

    Case 8-1

    Case 8-2

    Chapter 9 The PERIPHERAL CIRCULATION AND ITS CONTROL

    The Functions of the Heart and Large Blood Vessels

    Contraction and Relaxation of Arteriolar Vascular Smooth Muscle Regulate Peripheral Blood Flow

    Cytoplasmic Ca++ Is Regulated to Control Contraction, via MLCK

    Contraction Is Controlled by Excitation-Contraction Coupling and/or Pharmacomechanical Coupling

    Control of Vascular Tone by Catecholamines

    Control of Vascular Contraction by Other Hormones, Other Neurotransmitters, and Autocoids

    Intrinsic Control of Peripheral Blood Flow

    Autoregulation and the Myogenic Mechanism Tend to Keep Blood Flow Constant

    The Endothelium Actively Regulates Blood Flow

    Tissue Metabolic Activity Is the Main Factor in the Local Regulation of Blood Flow

    Extrinsic Control of Peripheral Blood Flow Is Mediated Mainly by the Sympathetic Nervous System

    Impulses That Arise in the Medulla Descend in the Sympathetic Nerves to Increase Vascular Resistance

    Sympathetic Nerves Regulate the Contractile State of the Resistance and Capacitance Vessels

    The Parasympathetic Nervous System Innervates Blood Vessels Only in the Cranial and Sacral Regions of the Body

    Epinephrine and Norepinephrine Are the Main Humoral Factors That Affect Vascular Resistance

    The Vascular Reflexes Are Responsible for Rapid Adjustments of Blood Pressure

    The Peripheral Chemoreceptors Are Stimulated by Decreases in Blood Oxygen Tension and pH and by Increases in Carbon Dioxide Tension

    The Central Chemoreceptors Are Sensitive to Changes in Paco2

    Other Vascular Reflexes

    Balance Between Extrinsic and Intrinsic Factors in Regulation of Peripheral Blood Flow

    Summary

    Case 9-1

    Chapter 10 CONTROL OF CARDIAC OUTPUT: COUPLING OF HEART AND BLOOD VESSELS

    Factors Controlling Cardiac Output

    The Cardiac Function Curve Relates Central Venous Pressure (Preload) to Cardiac Output

    Preload or Filling Pressure of the Heart

    Cardiac Function Curve

    Factors That Change the Cardiac Function Curve

    The Vascular Function Curve Relates Central Venous Pressure to Cardiac Output

    Mathematical Analysis of the Vascular Function Curve

    Venous Pressure Depends on Cardiac Output

    Blood Volume

    Venomotor Tone

    Blood Reservoirs

    Peripheral Resistance

    Cardiac Output and Venous Return Are Closely Associated

    The Heart and Vasculature Are Coupled Functionally

    Myocardial Contractility

    Blood Volume

    Peripheral Resistance

    The Right Ventricle Regulates Not Only Pulmonary Blood Flow but Also Central Venous Pressure

    Heart Rate Has Ambivalent Effects on Cardiac Output

    Ancillary Factors Affect the Venous System and Cardiac Output

    Gravity

    Muscular Activity and Venous Valves

    Respiratory Activity

    Artificial Respiration

    Summary

    Case 10-1

    Chapter 11 CORONARY CIRCULATION

    Functional Anatomy of the Coronary Vessels

    Coronary Blood Flow Is Regulated by Physical, Neural, and Metabolic Factors

    Physical Factors

    Neural and Neurohumoral Factors

    Metabolic Factors

    Diminished Coronary Blood Flow Impairs Cardiac Function

    Energy Substrate Metabolism During Ischemia

    Coronary Collateral Vessels Develop in Response to Impairment of Coronary Blood Flow

    Summary

    Case 11-1

    Chapter 12 SPECIAL CIRCULATIONS

    Cutaneous Circulation

    Skin Blood Flow Is Regulated Mainly by the Sympathetic Nervous System

    Ambient Temperature and Body Temperature Play Important Roles in the Regulation of Skin Blood Flow

    Skin Color Depends on the Volume and Flow of Blood in the Skin and on the Amount of O2 Bound to Hemoglobin

    Skeletal Muscle Circulation

    Regulation of Skeletal Muscle Circulation

    Cerebral Circulation

    Local Factors Predominate in the Regulation of Cerebral Blood Flow

    The Pulmonary and Systemic Circulations Are in Series with Each Other

    Functional Anatomy

    Pulmonary Hemodynamics

    Regulation of the Pulmonary Circulation

    The Renal Circulation Affects the Cardiac Output

    Anatomy

    Renal Hemodynamics

    The Renal Circulation Is Regulated by Intrinsic Mechanisms

    The Splanchnic Circulation Provides Blood Flow to the Gastrointestinal Tract, Liver, Spleen, and Pancreas

    Intestinal Circulation

    Hepatic Circulation

    Fetal Circulation

    Changes in the Circulatory System at Birth

    Summary

    Case 12-1

    Case 12-2

    Case 12-3

    Chapter 13 INTERPLAY OF CENTRAL AND PERIPHERAL FACTORS THAT CONTROL THE CIRCULATION

    Exercise

    Mild to Moderate Exercise

    Severe Exercise

    Postexercise Recovery

    Limits of Exercise Performance

    Physical Training and Conditioning

    Hemorrhage

    Hemorrhage Evokes Compensatory and Decompensatory Effects on the Arterial Blood Pressure

    The Compensatory Mechanisms Are Neural and Humoral

    The Decompensatory Mechanisms Are Mainly Humoral, Cardiac, and Hematologic

    The Positive and Negative Feedback Mechanisms Interact

    Summary

    Case 13-1

    Case 13-2

    Appendix A: End-of-Chapter CASE STUDY ANSWERS

    Appendix B: Comprehensive Examination

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